SENNA TORA LEAF EXTRACT'S EFFECTS ON DIABETIC ALBINO RATS' BLOOD GLUCOSE LEVELS
CHAPTER ONE
1.0 Introduction
Diabetes mellitus is a disease in which blood vessels of glucose (sugar) are high because the body does not produce or properly use insulin. There are two major forms of diabetes mellitus. Type 1 diabetes develops when the pancreas does not produce insulin. Type 2 diabetes occurs when the body cell resist insulin’s effect (Microsoft Encarta, 2009). This condition leads to elevated levels of blood glucose. The normal range of blood glucose level for blood glucose level is between 70-110mg/dl. Insulin is a hormone that helps to maintain normal blood glucose level by making the body’s cell absorbs glucose (sugar) so that it can be as a source of energy.
In people with diabetes glucose levels build up in the blood and urine causing excessive urination, thirst, hunger and problems with fats and protein metabolism because the body cannot convert glucose into energy, it begins to break down stored fats for fuel. This produces increasing amounts of acidic compounds in the blood called ketone bodies which interfere with cellular respiration energy producing process in cells. Alloxan induces diabetes mellitus in rats. Alloxan, a beta cytotoxin, induces diabetes in a wide variety of animal species through damage of insulin secreting cell. In these animals, with characteristic similar to type 1 diabetes in humans. Hypercholesterolemia and hypertriglyceridemia are common complications of diabetes mellitus. (Rerup, C. C. 1999).
Senna tora (originally described by Linne as cassia tora) is a legume in the subfamily caesalpiniodeae. It grows wild in most of the tropics and is considered a weed in many places. Its native range is not well known but probably South Asia. It is often confused with Chinese senna or sickle pods obtusifolia. If it is given a distinct common name at all, it is called sickle wild sensitive plant (nature serve, 200). It has a widely ranging tropical and the agro climatic conditions, which are conducive for introducing and domesticating new and exotic plant varieties.
The use of the plants, plant extracts and pure compounds isolated from natural sources provided the foundation to modern pharmaceutical compounds. An ethno botanical search on fine species senna within and around Ogbomoso, Oyo state, Nigeria showed their relevance in the local herbal medicine. In the recent study, screening for hypoglycemic activity of the extract of senna tora was conducted to provide support for the use of this plant as traditional medicine. Phytochemical screening provides knowledge of the chemical constituents of this not only for the discovery of new therapeutic agents, but also for information in discovering new sources of other materials. The uses of senna tora include the following, used as liver stimulant, mild laxative, heart tonic, used in treatment of fever, used to treat eczema and dermatomycosis, etc.
1.1 Aims And Objectives Of The Research
Therefore the goal of the study is to:
- To determining the blood glucose levels of normal and Alloxan induced diabetic rats.
- To determine the effects of senna tora leaves extract on the blood glucose levels of the diabetic albino rats.
- To compare values before and after induction with Alloxan and senna tora leaves.
CHAPTER TWO
2.0 Literature Review
2.1 Introduction
The review of relevant literature is the main topic of this chapter. A literature review covers theoretical and methodological contributions to a certain issue in addition to the state of knowledge at the time of writing. It provides information about the state of the art in relation to the subject you are writing about. It examines the body of work on the chosen subject. The literature evaluation in this study comprises the …
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TABLE OF CONTENTSPRELIMINARY PAGES
- Title page
- Approval page
- Dedication
- Acknowledgement
- Table of Contents
- Abstract
INTRODUCTION
- 1.0 Introduction
- ⋮
LITERATURE REVIEW
- 2.1 Introduction
- ⋮
CHAPTER THREE
MATERIALS AND METHODS
- 3.1 Introduction
- ⋮
CHAPTER FOUR
RESULTS AND DISCUSSION
- 4.1 Introduction
- 4.2 Results
- ⋮
- 4.3 Discussion of Findings
CHAPTER FIVE
SUMMARY, CONCLUSION AND RECOMMENDATION
- 5.1 Introduction
- 5.2 Summary
- 5.3 Conclusion
- 5.4 Recommendation
REFERENCES
Disclaimer for Complete Material Utilization
The displayed research work titled "Senna Tora Leaf Extract's Effects on Diabetic Albino Rats' Blood Glucose Levels" is stated as a research guideline towards accomplishing your assigned project / seminar research work. All the research materials on this website are ONLY for research purposes and should be used as a guideline in developing your research work. For no reason should you copy word for word as projectlist.com.ng will not be liable for any who copied the material. By ordering the complete research guideline, it signifies that you've accepted our terms of service.
PRELIMINARY PAGES
- Title page
- Approval page
- Dedication
- Acknowledgement
- Table of Contents
- Abstract
INTRODUCTION
- 1.0 Introduction
- ⋮
LITERATURE REVIEW
- 2.1 Introduction
- ⋮
CHAPTER THREE
MATERIALS AND METHODS
- 3.1 Introduction
- ⋮
CHAPTER FOUR
RESULTS AND DISCUSSION
- 4.1 Introduction
- 4.2 Results
- ⋮
- 4.3 Discussion of Findings
CHAPTER FIVE
SUMMARY, CONCLUSION AND RECOMMENDATION
- 5.1 Introduction
- 5.2 Summary
- 5.3 Conclusion
- 5.4 Recommendation
REFERENCES
Disclaimer for Complete Material Utilization
The displayed research work titled "Senna Tora Leaf Extract's Effects on Diabetic Albino Rats' Blood Glucose Levels" is stated as a research guideline towards accomplishing your assigned project / seminar research work. All the research materials on this website are ONLY for research purposes and should be used as a guideline in developing your research work. For no reason should you copy word for word as projectlist.com.ng will not be liable for any who copied the material. By ordering the complete research guideline, it signifies that you've accepted our terms of service.
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