ESTIMATION OF SERUM LLIPIDS (TOTAL CHOLESTEROL, HDL CHOLESTEROL AND LDL CHOLESTEROL IN ALLOXAN INDUCED DIABETIC WISTER RATS)
ABSTRACT
This research work assessed the hypoglycaemic effect of canavaelia ensiforoms and its relationship with serum lipids (total cholesterol, HDL — cholesterol and LDL — cholesterol) in an alloxan induced diabetic rat. Diabetes was induced using 100mg/kg during weight of a 5% stock solution of alloxan. Three were four groups and they were divided into group treated with 200mg/kg body weight of the plant extract, group treated with 400mg/kg body weight of the plant extract, diabetic control group and normal control group. The result after 14 days of treatment with the plant extract showed significant reduction in blood glucose concentration in diabetic rat treated with 200mg/kg of plant extract (94.5 + 25.22mg/dl) as compared to the diabetic control rats (38016 + 133.01mg/dl).
The effect of the plant extract an serum total cholesterol in diabetic treated rats with 200mg/kg body of (ensiforms also decreased significantly (118.20 + 24.55mg/dl) is compared to the diabetic control rats (201.84 + 61.55mg/dL).
In addition, there was significant increase in the HDL — cholesterol of the diabetic rat treated with 200mg/kg body weight of the plant extract (57.54 + 16.31mg/dL) as compared to the diabetical rat (3286 + 7.42mg/dL). Finding, there was significant reduction in the LDL — cholesterol of the diabetic rat treated with 200mg/kg body weight of the plant extract (51.59 + 29.82mg/dL) as compared to the diabetic control (133.44 + 57.39mg/dL). Thus, canavalin ensiform extract reduces blood glucose, total cholesterol, LDL — cholesterol and increase HDL — cholesterol.
CHAPTER ONE
1.0 Introduction
The use of dietary legumes have been reported to influence glycoami and lipiddaemia in man and experimental animals. (Mahnow et l. 1980; Bingwem et al., 1981, Molgaard et l. 1987; Donatucei et al. 1987).
(anaralis ensiformis DC (family: leguminosaae) variously known as jack beans, though a nature of central America and west idnies has been widely cultivated in the Lumed tropics of Africa and Asia. The seeds have been reported to possess antihypercholesterolaemic (Marfo et al., 1990) and hypoglycemic (enyikwola et al., 1991) activities.
Diabetics mellitus is a syndrome characterizing by chronic hyperglycemic and disturbances of carbohydrate, fat and protein metabolism associated with absolute or relative deficiencies in insulin secretion and/or insulin action (Bennet, 1994).
Patients, with this disease are generally classified as either type I (insulin dependent) or type 2 (non — insulin and dependent) diabetics. For oth types of diabetes, control of blood glucose levels, lipids leels,blood pressure and weight will reduce the rise of vascular problems and associated diseases (Williams, 1994).
Earlier work on the effect of (ensiforms on normal and alloxan induced diabetic rats showed statistically significant decreases in blood and arising urinary glucose weight loss to the treated diabetic animals (Nimen bo — Uadia and Osagie, 1999).
This study reports the effect of C. ensiforms on total senior cholesterol, HSL — cholesterol and LDL — cholesterol in alloxan — induced diabetic rats.
CHAPTER TWO
2.0 Literature Review
2.1 Introduction
The review of relevant literature is the main topic of this chapter. A literature review covers theoretical and methodological contributions to a certain issue in addition to the state of knowledge at the time of writing. It provides information about the state of the art in relation to the subject you are writing about. It examines the body of work on the chosen subject. The literature evaluation in this study comprises the …
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TABLE OF CONTENTSPRELIMINARY PAGES
- Title page
- Approval page
- Dedication
- Acknowledgement
- Table of Contents
- Abstract
INTRODUCTION
- 1.0 Introduction
- ⋮
LITERATURE REVIEW
- 2.1 Introduction
- ⋮
CHAPTER THREE
MATERIALS AND METHODS
- 3.1 Introduction
- ⋮
CHAPTER FOUR
RESULTS AND DISCUSSION
- 4.1 Introduction
- 4.2 Results
- ⋮
- 4.3 Discussion of Findings
CHAPTER FIVE
SUMMARY, CONCLUSION AND RECOMMENDATION
- 5.1 Introduction
- 5.2 Summary
- 5.3 Conclusion
- 5.4 Recommendation
REFERENCES
Disclaimer for Complete Material Utilization
The displayed research work titled "Estimation of Serum Llipids (Total Cholesterol, HDL Cholesterol and LDL Cholesterol in Alloxan Induced Diabetic Wister Rats)" is stated as a research guideline towards accomplishing your assigned project / seminar research work. All the research materials on this website are ONLY for research purposes and should be used as a guideline in developing your research work. For no reason should you copy word for word as projectlist.com.ng will not be liable for any who copied the material. By ordering the complete research guideline, it signifies that you've accepted our terms of service.
PRELIMINARY PAGES
- Title page
- Approval page
- Dedication
- Acknowledgement
- Table of Contents
- Abstract
INTRODUCTION
- 1.0 Introduction
- ⋮
LITERATURE REVIEW
- 2.1 Introduction
- ⋮
CHAPTER THREE
MATERIALS AND METHODS
- 3.1 Introduction
- ⋮
CHAPTER FOUR
RESULTS AND DISCUSSION
- 4.1 Introduction
- 4.2 Results
- ⋮
- 4.3 Discussion of Findings
CHAPTER FIVE
SUMMARY, CONCLUSION AND RECOMMENDATION
- 5.1 Introduction
- 5.2 Summary
- 5.3 Conclusion
- 5.4 Recommendation
REFERENCES
Disclaimer for Complete Material Utilization
The displayed research work titled "Estimation of Serum Llipids (Total Cholesterol, HDL Cholesterol and LDL Cholesterol in Alloxan Induced Diabetic Wister Rats)" is stated as a research guideline towards accomplishing your assigned project / seminar research work. All the research materials on this website are ONLY for research purposes and should be used as a guideline in developing your research work. For no reason should you copy word for word as projectlist.com.ng will not be liable for any who copied the material. By ordering the complete research guideline, it signifies that you've accepted our terms of service.
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